The Duration of Motor Responses Evoked with Intracortical Microstimulation in Rats Is Primarily Modulated by Stimulus Amplitude and Train Duration
Identifieur interne : 000181 ( Main/Exploration ); précédent : 000180; suivant : 000182The Duration of Motor Responses Evoked with Intracortical Microstimulation in Rats Is Primarily Modulated by Stimulus Amplitude and Train Duration
Auteurs : Meghan Watson [Canada] ; Mohamad Sawan [Canada] ; Numa Dancause [Canada]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
Microstimulation of brain tissue plays a key role in a variety of sensory prosthetics, clinical therapies and research applications, however the effects of stimulation parameters on the responses they evoke remain widely unknown. In particular, the effects of parameters when delivered in the form of a stimulus train as opposed to a single pulse are not well understood despite the prevalence of stimulus train use. We aimed to investigate the contribution of each parameter of a stimulus train to the duration of the motor responses they evoke in forelimb muscles. We used constant-current, biphasic, square wave pulse trains in acute terminal experiments under ketamine anaesthesia. Stimulation parameters were systematically tested in a pair-wise fashion in the caudal forelimb region of the motor cortex in 7 Sprague-Dawley rats while motor evoked potential (MEP) recordings from the forelimb were used to quantify the influence of each parameter in the train. Stimulus amplitude and train duration were shown to be the dominant parameters responsible for increasing the total duration of the MEP, while interphase interval had no effect. Increasing stimulus frequency from 100–200 Hz or pulse duration from 0.18–0.34 ms were also effective methods of extending response durations. Response duration was strongly correlated with peak time and amplitude. Our findings suggest that motor cortex intracortical microstimulations are often conducted at a higher frequency rate and longer train duration than necessary to evoke maximal response duration. We demonstrated that the temporal properties of the evoked response can be both predicted by certain response metrics and modulated via alterations to the stimulation signal parameters.
Url:
DOI: 10.1371/journal.pone.0159441
PubMed: 27442588
PubMed Central: 4956212
Affiliations:
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by Stimulus Amplitude and Train Duration</title><author><name sortKey="Watson, Meghan" sort="Watson, Meghan" uniqKey="Watson M" first="Meghan" last="Watson">Meghan Watson</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Polystim Neurotechnologies, Institute of Biomedical Engineering, Polytechnique, Montreal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Polystim Neurotechnologies, Institute of Biomedical Engineering, Polytechnique, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Département de Neurosciences, Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Département de Neurosciences, Faculté de Médecine, Université de Montréal, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Sawan, Mohamad" sort="Sawan, Mohamad" uniqKey="Sawan M" first="Mohamad" last="Sawan">Mohamad Sawan</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Polystim Neurotechnologies, Institute of Biomedical Engineering, Polytechnique, Montreal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Polystim Neurotechnologies, Institute of Biomedical Engineering, Polytechnique, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Dancause, Numa" sort="Dancause, Numa" uniqKey="Dancause N" first="Numa" last="Dancause">Numa Dancause</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Département de Neurosciences, Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada</addr-line></nlm:aff><country 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sensory prosthetics, clinical therapies and research applications, however the effects of stimulation parameters on the responses they evoke remain widely unknown. In particular, the effects of parameters when delivered in the form of a stimulus train as opposed to a single pulse are not well understood despite the prevalence of stimulus train use. We aimed to investigate the contribution of each parameter of a stimulus train to the duration of the motor responses they evoke in forelimb muscles. We used constant-current, biphasic, square wave pulse trains in acute terminal experiments under ketamine anaesthesia. Stimulation parameters were systematically tested in a pair-wise fashion in the caudal forelimb region of the motor cortex in 7 Sprague-Dawley rats while motor evoked potential (MEP) recordings from the forelimb were used to quantify the influence of each parameter in the train. Stimulus amplitude and train duration were shown to be the dominant parameters responsible for increasing the total duration of the MEP, while interphase interval had no effect. Increasing stimulus frequency from 100–200 Hz or pulse duration from 0.18–0.34 ms were also effective methods of extending response durations. Response duration was strongly correlated with peak time and amplitude. Our findings suggest that motor cortex intracortical microstimulations are often conducted at a higher frequency rate and longer train duration than necessary to evoke maximal response duration. We demonstrated that the temporal properties of the evoked response can be both predicted by certain response metrics and modulated via alterations to the stimulation signal parameters.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dobelle, Wh" uniqKey="Dobelle W">WH Dobelle</name></author><author><name sortKey="Mladejovsky, Mg" uniqKey="Mladejovsky M">MG Mladejovsky</name></author><author><name sortKey="Girvin, Jp" uniqKey="Girvin J">JP Girvin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidt, Em" uniqKey="Schmidt E">EM Schmidt</name></author><author><name sortKey="Bak, Mj" uniqKey="Bak M">MJ Bak</name></author><author><name sortKey="Hambrecht, Ft" uniqKey="Hambrecht F">FT Hambrecht</name></author><author><name sortKey="Kufta, Cv" uniqKey="Kufta C">CV Kufta</name></author><author><name sortKey="O Ourke, Dk" uniqKey="O Ourke D">DK O’Rourke</name></author><author><name 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Kurata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Evans, Jd" uniqKey="Evans J">JD Evans</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hill, Av" uniqKey="Hill A">AV Hill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Wieringen, A" uniqKey="Van Wieringen A">A van Wieringen</name></author><author><name sortKey="Macherey, O" uniqKey="Macherey O">O Macherey</name></author><author><name sortKey="Carlyon, Rp" uniqKey="Carlyon R">RP Carlyon</name></author><author><name sortKey="Deeks, Jm" uniqKey="Deeks J">JM Deeks</name></author><author><name sortKey="Wouters, J" uniqKey="Wouters J">J Wouters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Ar" uniqKey="Brown A">AR Brown</name></author><author><name sortKey="Teskey, Gc" uniqKey="Teskey G">GC Teskey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Griffin, Dm" uniqKey="Griffin D">DM Griffin</name></author><author><name sortKey="Hudson, Hm" uniqKey="Hudson H">HM Hudson</name></author><author><name sortKey="Belhaj Saif, A" uniqKey="Belhaj Saif A">A Belhaj-Saïf</name></author><author><name sortKey="Cheney, Pd" uniqKey="Cheney P">PD Cheney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rathelot, J A" uniqKey="Rathelot J">J-A Rathelot</name></author><author><name sortKey="Strick, Pl" uniqKey="Strick P">PL Strick</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Watson, Meghan" sort="Watson, Meghan" uniqKey="Watson M" first="Meghan" last="Watson">Meghan Watson</name></noRegion><name sortKey="Dancause, Numa" sort="Dancause, Numa" uniqKey="Dancause N" first="Numa" last="Dancause">Numa Dancause</name><name sortKey="Dancause, Numa" sort="Dancause, Numa" uniqKey="Dancause N" first="Numa" last="Dancause">Numa Dancause</name><name sortKey="Sawan, Mohamad" sort="Sawan, Mohamad" uniqKey="Sawan M" first="Mohamad" last="Sawan">Mohamad Sawan</name><name sortKey="Watson, Meghan" sort="Watson, Meghan" uniqKey="Watson M" first="Meghan" last="Watson">Meghan Watson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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